Novel Therapies to Treat Muscle Wasting in Cancer

Grant number: 1041865 | Funding period: 2013 - 2016

Completed

Abstract

Cancer cachexia is a devastating disease characterised by muscle wasting, weakness and fatigue. It impairs patient quality of life and accounts for >20% of cancer-related deaths. This project will identify factors responsible for cancer cachexia and develop new strategies to alleviate wasting and weakness in cancer patients, to improve their quality of life and reduce mortality.

Related publications (5)

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Altering phosphorylation of dystrophin S3059 to attenuate cancer cachexia

K Swiderski, J Trieu, A Chee, T Naim, CJ Brock, DM Baum, AS Chan, JP Hardee, W Li, AJ Kueh, MJ Herold, KT Murphy, P Gregorevic, GS Lynch

2025-02-01

Aims: Cancer cachexia affects up to 80 % of patients with advanced cancer and accounts for >20 % of all cancer-related deaths. Sar..

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Mechanisms of chemotherapy‐induced muscle wasting in mice with cancer cachexia

Kate T Murphy, Kristy Swiderski, James G Ryall, Jonathan R Davey, Hongwei Qian, Séverine Lamon, Victoria C Foletta, Jennifer Trieu, Annabel Chee, Suzannah J Read, Timur Naim, Paul Gregorevic, Gordon S Lynch

2022-01-01

<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Cachexia is a debilitating complication of c..

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Murine models of Duchenne muscular dystrophy: is there a best model?

K Swiderski, GS Lynch

2021-08-01

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Phosphorylation of ERK and dystrophin S3059 protects against inflammationassociated C2C12 myotube atrophy

K Swiderski, CJ Brock, J Trieu, A Chee, SS Thakur, DM Baum, P Gregorevic, KT Murphy, GS Lynch

2021-06-01

The dystrophin-glycoprotein complex (DGC) is a multiprotein structure required to maintain muscle fiber membrane integrity, transm..

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MAs receptor activation slows tumor growth and attenuates muscle wasting in cancer

KT Murphy, MI Hossain, K Swiderski, A Chee, T Naim, J Trieu, V Haynes, SJ Read, DI Stapleton, SM Judge, JG Trevino, AR Judge, GS Lynch

2019-02-15

Cancer cachexia is a multifactorial syndrome characterized by a progressive loss of skeletal muscle mass associated with significa..

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